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<h2>GPR83: A Novel Treg Expressed Cell Surface Marker</h2>by Stephen Jones 
 
As research continues to unravel the molecular basis of 
regulatory T cells (Treg), FOXP3 has 
emerged as a key player in orchestrating development and function of natural 
Treg. Two recent publications identified GPR83 as specifically upregulated in 
fresh and activated CD4+ CD25+ Treg cells. Both groups performed gene 
expression profiling on Treg, and other T cells to identify differentially 
regulated genes. Sugimoto et al. performed additional mRNA and protein 
expression analysis based on the results of their micro array analysis using 
RT-PCR as well as FACS analysis of GPR83 using anti-GPR83 antibody. These 
recent findings suggest that GPR83 may be useful as a specific and stable cell 
surface marker with modulatory properties, and a key molecule for further 
characterizing the molecular basis of Tregs. IMGENEX proudly offers this Flow 
and IHC positive GPR83 antibody (IMG-71561), as well as other GPR83, FOXP3, and CD marker antibodies for 
your Treg research. 
 
<o:p> </o:p> 
 
Key Publication 
Findings<o:p /> 
 
�GPR83 is upregulated in both 
murine and human Treg � Gene analysis, mRNA, and protein expression show that 
GPR83 is upregulated in FOXP3+ cells 
 
� GPR83 is expressed in both fresh 
and activated Treg 
 
� GPR83 appears to be FOXP3 
dependent, although Hansen et al. suggests that induction of FOXP3+ 
 
Treg by GPR83 occurs in vivo, 
suggesting a more complex relationship 
 
� GPR83 is found in both Thymus 
and Spleen/LN CD4 and CD25 cells 
 
� Foxp3 retroviral transduced 
CD25- CD4+ cells induces GPR83 expression at much higher levels than 
mock-transduced cells 
 
� Suggests a possible ligand that 
binds to GPR83 in vivo which confers to these cells suppressive activity. 
 
 
<h3>About the Author</h3>

IMGENEX India Pvt Ltd. the only
biotech company in Orissa and one of its kinds in <st1:place w:st="on">Eastern
 India</st1:place>. IMGENEX India started in Oct as an outsourcing branch of  <a href="http://www.imgenex.com">IMGENEX Corporation</a> , <st1:place w:st="on"><st1:city w:st="on">San Diego</st1:city>, <st1:country-region w:st="on">USA</st1:country-region></st1:place>.  Find out more information about   <a href="http://www.imgenex.com/antibody_details.php?catalog=IMG-71561">GPR83
& FOXP3 Treg</a> .

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