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<h2>GPCRs: Exploring New Paradigms</h2>by Stephen Jones 
 
As one of the largest and most diverse protein families in nature, 
the <a href="http://www.imgenex.com/emarketing/061606GPCR/GPCRAntibodies4.htm"> 
G-protein coupled receptor (GPCR) </a> superfamily play important roles 
in a variety of biological and pathological processes such as development and 
proliferation, neuromodulation, angiogenesis, metabolic disorders, 
inflammation, and viral infection.  Not surprisingly, it is one of the 
most targeted protein families in pharmaceutical research today (Schlyer 
2006).  
 
All members of this superfamily share a similar seven transmembrane domain, but 
are grouped on the basis of shared sequence motifs  into the following 
broad classes: 
 
 
 
Class A Rhodopsin-like 
Class B Secretin-like 
Class C Metabotropic glutamate/pheromone 
Class D Fungal pheromone 
Class E cAMP receptors 
Frizzled/Smoothened 
Vomeronasal receptors 
Putative/unclassified 
 
The pharmaceutical industry has focused on development of modulators to this 
protein family, but GPCRs also represent an attractive target as 
biomarkers.  Recent studies have implicated endothelin receptors, 
chemokine receptors and lysophosphatidic acid receptors in tumorgenesis and 
metastasis, and a recent in silico analysis found a number of 
GPCRs that were up-regulated in various cancers which suggests not only targets 
of therapeutic value, but of diagnostic and prognostic value as well.  A 
summary of these up-regulated receptors is below. 
 
Lung cancer 
Edg2, P2Y purinoceptor 6, PAR-2, PAR-3,  GPR68 
Breast cancer 
CCR1, CXCR-4, PAR-2 
Prostate cancer 
Beta 2 adrenergic receptor, CXCR-3, CXCR-4, GPR68 
Melanoma 
Edg6, PAR-2, mGluR1 
Gastric cancer 
CXCR-4, P2Y purinoceptor 5 
Lymphoma 
Beta 2 adrenergic receptor, Edg1, CCR7 
 
  
 
While 
research continues, it is evident that GPCRs are critical in countless 
biological functions--and disfunctions.  While the emphasis is on their 
role in drug development, it is becoming increasingly clear that G-protein 
coupled receptors will play a critical role as indicators of disease with 
diagnostic and prognostic potential. IMGENEX carries over 900 IHC, WB, and flow 
validated GPCR antibodies.  View our complete <a  href="http://imgenex.com/view_data_page.php?id=94">GPCRs 
</a> antibody list grouped by class and family. Also <a 
href="http://www.imgenex.com/tissue_array.php">see</a> our 
complete list of Tissue Microarray slides--perfect for GPCR localization.<o:p /> 
 
 
<h3>About the Author</h3>

IMGENEX India Pvt Ltd. the only biotech company in Orissa
and one of its kinds in <st1:place w:st="on">Eastern India</st1:place>. IMGENEX
India started in Oct as an outsourcing branch of <a href="http://www.imgenex.com">IMGENEX
Corporation</a> ,<st1:place w:st="on"><st1:city w:st="on">San Diego</st1:city>,
 <st1:country-region w:st="on">USA</st1:country-region></st1:place>.

Find out more information about  <a href="http://www.imgenex.com/gpcr.php">GPCRs</a> ,<a href="http://www.imgenex.com/Gprotein_receptors.php">G-protein</a>
coupled receptor.

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