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<h2>Epigenetic and Signal Transduction Reagents</h2>by Stephen Jones 
 
IMGENEX offers over 90 Chromatin, DNA Methylation & 
Repair, and DNA Fragmentation-related antibodies, many of which have been cited 
in numerous peer-reviewed journals.  
These antibodies have been used to study transcriptional silencing, 
identify DNA-protein interactions, and characterize the sequence of molecular 
binding events. 
 
<o:p> </o:p> 
 
Surging interest in understanding the mechanisms of 
epigenetics is attracting researchers worldwide from a wide variety of scientific 
disciplines. Epigenetics is the study of the heritable changes in gene function 
that occur without changes in DNA sequence.  
It is becoming increasingly apparent that an epigenetic phenomenon is 
integral to both normal and aberrant gene regulation. 
 
<o:p> </o:p> 
 
Histone proteins are thought to be the major carriers of 
epigenetic information. Histones form the nucleosomal complexes that make up 
the eukaryotic chromatin, which packages and organizes DNA in the nucleus. The 
nucleosome, the basic repeating subunit of chromatin, is composed of DNA coiled 
around an octamer of two molecules, each with four core histone proteins: H2A, 
H2B, H3 and H4.  Each core histone is 
composed of a structured, three-helix domain called the "histone 
fold" and two unstructured tails. 
 
<o:p> </o:p> 
 
The N-terminal histone tails extend outward from the 
DNA to interact with the nuclear environment where they are the targets of 
multiple, diverse signaling pathways.  
Signal transduction pathways impinging on the N-terminal histone tails 
result in a number of post-translational modifications including acetylation, 
phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation.  These modifications play critical roles in 
regulating chromatin structure and gene expression. 
<h3>About the Author</h3>

IMGENEX India Pvt Ltd. the only biotech company in Orissa
and one of its kinds in <st1:place w:st="on">Eastern India</st1:place>. IMGENEX
India started in Oct as an outsourcing branch of <a href="http://www.imgenex.com">IMGENEX Corporation</a> ,<st1:place w:st="on"><st1:city w:st="on">San Diego</st1:city>, <st1:country-region w:st="on">USA</st1:country-region></st1:place>.
Find out more  information about  <a href="http://www.imgenex.com/DNAMethylation.php">Epigenetics</a> .

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