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Here is Akt Family: Antibodies from Imgenex formatted for use on a website.

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<h2>Akt Family: Antibodies from Imgenex</h2>by Stephen Jones 
 
Akt family of 
serine/threonine-directed kinases regulates a diverse array of 
biological processes, including cellular survival, proliferation, 
glucose homeostasis, and vascular tone and are important molecules in mammalian cellular 
signaling. The three widely expressed isoforms of PKB (PKB<img width="8" height="6" id="_x0000_i1025" src="http://jcs.biologists.org/math/alpha.gif" alt="{alpha}" />, PKB� and PKB<img width="9" height="11" id="_x0000_i1026" src="http://jcs.biologists.org/math/gamma.gif" alt="{gamma}" />; also known as 
Akt1, Akt2 and Akt3, respectively) are each composed of an 
N-terminal PtdIns(3,4,5)P3- and PtdIns(3,4)P2-binding 
PH domain and a C-terminal kinase catalytic domain. Stimulation by 
numerous growth factors, cytokines, hormones and neurotransmitters can activate 
PKB/Akt in a phosphoinositide 3-kinase-dependent manner. Through receptor 
tyrosine kinases, these stimuli cause phosphoinositide 3-kinase activation, and 
generation of the membrane phospholipid PtdIns(3,4,5)P3. PtdIns(3,4,5)P3 
then recruits PKB/Akt to the membrane, where it becomes phosphorylated (for PKBa/Akt1) by upstream kinases, 
phosphoinositide-dependent kinase 1. Following the activation of PI 
3-kinase, PKB isoforms are recruited from the cytosol to the plasma 
membrane through their interaction with PtdIns(3,4,5)P3 
and/or PtdIns(3,4)P2 where they are thought to 
undergo a conformational change and become activated by phosphorylation of 
two residues. PKB can promote cell survival by inhibiting proteins that mediate 
apoptosis. Phosphorylation of BAD by PKB (and other AGC kinases) 
enables it to interact with 14-3-3 proteins, which prevents it from 
binding to Bcl-XL and thereby suppresses apoptosis. It 
directly phosphorylate and inhibit the caspase proteasesm, key executioners of 
apoptosis.  PKBbeta, an essential gene 
for the maintenance of normal glucose homeostasis and is likely to 
represent a critical intermediate in the insulin signal transduction 
pathway. PKB activation might inhibit apoptosis by promoting the 
increased expression of survival molecules or the degradation of 
pro-apoptotic molecules. PKB also phosphorylates and activates endothelial 
nitric oxide synthase, thereby promoting angiogenesis (formation of 
new blood vessels). Inhibition of GSK3 following its phosphorylation 
by PKB has also been suggested to play a role in inhibiting 
apoptosis in neuronal cells. Thus it plays a key role in cancer 
progression by stimulating cell proliferation and inhibiting 
apoptosis, which suggests it, likely to be a hot drug target for the treatment 
of cancer, diabetes and stroke. 
 
 
<h3>About the Author</h3>

IMGENEX India Pvt Ltd. the only
biotech company in Orissa and one of its kinds in <st1:place w:st="on">Eastern
 India</st1:place>. IMGENEX India started in Oct as an outsourcing branch of <a href="http://www.imgenex.com">IMGENEX Corporation</a>,
<st1:place w:st="on"><st1:city w:st="on">San Diego</st1:city>, <st1:country-region w:st="on">USA</st1:country-region></st1:place>.  Find out more information about  <a href="http://www.imgenex.com/search_result.php?txtSearch=akt">Akt
Family</a>.<o:p />

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